Reducing Early Exposure to Calcineurin Inhibitors: The Key Factor for a Successful Renal Sparing Strategy

Reduced exposure to calcineurin inhibitors in renal transplantation.

BACKGROUND Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens. METHODS We randomly assigned 1645 renal-transplant recipients to receive standard-dose cyclosporine, mycophenolate mofetil, and corticosteroids, or daclizumab induction, mycophenol...

Calcineurin inhibitors in paediatric renal transplantation

(Suggestions are based on Level III and IV evidence) • In children treated with cyclosporin, 2 h peak cyclosporin level (C2) monitoring should be used in the initial post-transplant period, as the C2 level is a better predictor of cyclosporin exposure than C0 monitoring (Level III evidence). Limited data suggest that the C2 level should be maintained above 1500 ng/mL in the early post-transplan...

Planning for postoperative care: a key strategy for reducing readmissions.

Early clinical exposure program in learning renal physiology

Introduction: Teaching renal physiology for undergraduatemedical students in an understandable way using methods whichimprove their deep learning has always been a problem. In thisstudy, Early Clinical Exposure (ECE) was used in teaching renalphysiology for the second year medical students in Shiraz MedicalSchool. This article aims to introduce and develop this programand also measure the attit...

a paradigm shift away from method-wise teaching to strategy-wise teaching: an investigation of reconstructive strategy versus communicative strategy

چکیده: هدف اصلی این مطالعه ی توصیفی تحقیقی در حقیقت تلاشی پساروش-گرا به منظور رسیدن به نتیجه ای منطقی در انتخاب مناسبترین راهکار آموزشی بر گرفته از چارچوب راهبردی مطرح شده توسط والدمر مارتن بوده که به بهترین شکل سازگار و مناسب با سامانه ی آموزشی ایران باشد. از این رو، دو راهکار آموزشی، راهکار ارتباطی و راهکار بازساختی، برای تحقیق و بررسی انتخاب شدند. صریحاً اینکه، در راستای هدف اصلی این پژوهش، ر...